Baseline liver fibrosis

Extent of liver fibrosis

Baseline liver fibrosis

Enhanced Liver Fibrosis (ELF) panel, Fibrometer, AST ALT ratio, Fib 4 score, Fibrotest (liver fibrosis).

Enhanced Liver Fibrosis (ELF) panel, Fibrometer, AST ALT ratio, Fib 4 score, Fibrotest (liver fibrosis)

Enhanced Liver Fibrosis (ELF) panel, Fibrometer, AST ALT ratio, Fib 4 score, Fibrotest (liver fibrosis)

Renal or hepatic impairment and liver fibrosis

fibrosis, cirrhosis, viral hepatitis, neonatal liver disease or congenital enzyme defects)

Table 10 SVR rates by extent of liver fibrosis at baseline Study 111

if you suffer from cirrhosis of the liver (a serious condition which causes liver scarring ).

Table 12 shows SVR rates by extent of liver fibrosis.

Table 12 SVR rates by extent of liver fibrosis at baseline Study C216

Focal hepatic fibrosis was observed in males and females and hepatic cystic degeneration was observed in males only.

compensated liver disease with evidence of active viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active liver inflammation and or fibrosis.

Table 10 shows SVR rates by extent of liver fibrosis at baseline.

No fibrosis, minimal fibrosis, or portal fibrosis

No or minimal fibrosis or portal fibrosis

In thalassaemia patients there is an association between liver fibrosis and iron overload and or hepatitis C.

No fibrosis or minimal fibrosis

compensated liver disease with evidence of active viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active liver inflammation and or fibrosis.

In particular, liver fibrosis was observed in dogs after administration of hydroxocobalamin for 4 weeks at 300 mg kg.

In particular, liver fibrosis was observed in dogs after administration of hydroxocobalamin for 4 weeks at 300 mg kg.

has chronic liver diseases known to represent preneoplastic conditions (e.g. advanced liver fibrosis, cirrhosis, viral hepatitis, neonatal liver disease or congenital enzyme defects)

Table 6 shows SVR rates by IL28B genotype and the stage of liver fibrosis at baseline.

Cystic Fibrosis

Pulmonary fibrosis

pleural effusion1)

Portal fibrosis

pulmonary fibrosis1)

Renal or hepatic impairment and liver fibrosis There are no data available on the use of deferiprone in patients with renal or hepatic impairment.

Patients with results suggesting the presence of steatohepatitis or fibrosis should be considered for liver biopsy.

There are a number of blood tests available that try to determine the degree of hepatic fibrosis and alleviate the need for biopsy.

Bridging fibrosis

Fibrosis stage

Idiopathic Pulmonary Fibrosis

METAVIR fibrosis score

It is used in adults with signs of ongoing liver injury (such as inflammation and fibrosis) when the liver is still working properly (compensated liver disease) and also when the liver is no longer working properly (decompensated liver disease).

In study HPC2002 (COSMOS), prior null responders with METAVIR fibrosis score F0 F2, or treatment naïve and prior null responder patients with METAVIR fibrosis score F3 F4 and compensated liver disease received simeprevir sofosbuvir, with or without ribavirin, for 12 or

28.4 (19 67) 14.2, 42.5

Cystic fibrosis patients

Fibrosis Score

Ishak Fibrosis Score3

leukocytoclastic vasculitis, skin fibrosis

Nephrogenic systemic fibrosis (NSF)

compensated liver disease with evidence of active viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active liver inflammation and fibrosis